Microsoft released the new OneDrive API today. See the blog post announcement here. One highlight is that large file upload is now officially supported. Previously, large file upload was handled with a semi-official API using the BITS protocol; the only documentation was a gist. Now it is handled through standard HTTP
POST. With this major release, there's likely a lot of work to be done with python-onedrive. I have opened an issue: mk-fg/python-onedrive#52 — New OneDrive API support.
Interestingly, the new OneDrive API doc is hosted on GitHub Pages — onedrive.github.io, rather than MSDN. Exactly a week ago I wrote a piece, "Microsoft is getting cool (but not its website)". Looks like they are doing something about their website (or better put, their online identity), too.